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The impact of influenza virus B in Italy: myth or reality?

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The Gartner Hype Cycle for Emerging Technologies, 2020

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We describe the burden of influenza B infections in Italy over a year study period. Influenza A and B viruses co-circulated throughout the period, with numbers of influenza B cases approaching or exceeding those of influenza A during three influenza seasons. Influenza B virus infections led to fewer admissions to an intensive care unit ICU and a lower mortality rate than influenza A from to This highlights the need for consistent influenza vaccination for identified risk groups.

Our study demonstrates that influenza B virus infections are associated with substantial morbidity and that influenza surveillance and interventions including vaccination and treatment are still suboptimal. Our findings have important public health implications. Incorporating virus and epidemiological data will help obtain more accurate estimates of influenza disease burden and result in a better selection of influenza prevention and control strategies.

The societal burden of seasonal influenza epidemics is quite heavy, with approximately million cases and ,, estimated deaths worldwide every year [ 1 ] and a large economic impact, which includes both direct and indirect costs [ 2 , 3 ]. Conventionally, attention has been directed toward influenza A, which accounts for the majority of influenza cases in most seasons [ 4 – 7 ]. However, influenza B can account for a considerable proportion of total cases [ 8 ].

Since the s, influenza B viruses have belonged to two antigenically distinct lineages, called the Victoria and Yamagata lineages [ 9 ]; this has constituted a challenge for seasonal influenza vaccines, as only one influenza B strain is included in the trivalent vaccine. Studies in the United States have shown that the frequent influenza B vaccine mismatches of recent years have been associated both with substantial increases in cases, hospitalizations and deaths up to , cases, with hospitalizations and deaths annually, in the USA [ 10 ], and with high influenza-related medical costs and costs due to productivity loss [ 11 ].

A Comprehensive COVID-19 Vaccine Plan

Average annual hours worked is defined as the total number of hours actually worked per year divided by the average number of people in employment per year. Actual hours worked include regular work hours of full-time, part-time and part-year workers, paid and unpaid overtime, hours worked in additional jobs, and exclude time not worked because of public holidays, annual paid leave, own illness, injury and temporary disability, maternity leave, parental leave, schooling or training, slack work for technical or economic reasons, strike or labour dispute, bad weather, compensation leave and other reasons.

The data cover employees and self-employed workers. This indicator is measured in terms of hours per worker per year. The data are published with the following health warning: The data are intended for comparisons of trends over time; they are unsuitable for comparisons of the level of average annual hours of work for a given year, because of differences in their sources and method of calculation. Compare variables.

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International Journal of Infectious Diseases

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Medicinal Research Reviews, ;33(2) by contacting L. Perasso, University of Genoa, Dept. of Internal Med & Cardionephrol, I Genoa, Italy.

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